Algorythm for treatment of Nausea and Vomiting in Pregnancy: if no improvement proceed to the next step |
Discontinue oral prenatal vitamins and iron. Give folic acid 1 mg PO once daily |
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Start doxylamine-pyridoxine long acting 10 mg-10 mg tab (DICLECTIN EQUIV). Typical starting dose: one tablet orally in the morning and afternoon, and two tablets orally before bed. Titrate dose up to 8 tablets a day and adjust schedule according to severity of symptoms. Note: DICLECTIN EQUIV is a delayed release tablet; administer regularly to improve efficacy |
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No Dehydration |
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Dehydration |
• dimenhyDRINATE 50 mg orally or rectally 1 hour before DICLECTIN EQUIV doses OR 50 mg orally or rectally Q6H (may increase up to Q4H regularly) • famotidine 20 mg PO BID |
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• IV rehydration • multivitamin IV supplementation once daily • dimenhyDRINATE 50 mg IV Q6H (may increase up to Q4H regularly) • famotidine 20 mg IV Q12H |
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Add • metoclopramide 10 mg PO Q8H |
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Add • metoclopramide 10 mg IV Q8H |
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Add • ondansetron 8 mg PO Q12H PRN OR 4 mg PO Q8H PRN (stop metoclopramide if previously given) |
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Add • ondansetron 8 mg IV Q12H PRN OR 4 mg IV Q8H PRN (stop metoclopramide if previously given) |
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• Bowel Care ○ If able to tolerate oral fluids give polyethylene glycol (PEG 3350) ○ glycerin adult suppository • Consider DVT prophylaxis while in hospital • Inpatients: in preparation for discharge from hospital, gradually change each IV medication to oral dose and route |
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Add • methylprednisolone 15 to 20 mg IV Q8H PRN for up to 24h |
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